Cordycepin inhibits rna synthesis
Surprisingly, combining tunicamycin or thapsigargin with a chemotherapeutic drug may induce apoptosis with an immunogenic effect in nature as well essays christmas english 56 ]. Death-inducing signaling complex containing FADD and pro-caspase-8 appear at the death receptor. It subsequently triggered mitochondrial membrane depolarization and led to apoptosis, although the role of ER stress in berberine treatment was not addressed.
Importantly, relieving ER stress by protein translation inhibitor cycloheximide impaired drug-induced apoptosis. Nrf2-mediated HO-1 upregulation was found in sulforaphane-treated bladder cancer T24 cells [ 26 ].
When the cellular environment changes or cells are affected by DNA damage and oxidative stress, misfolding proteins may accumulate in the ER leading to increased ER stress. Mechanistically, it has been shown that hypericin is a photosensitizer that promotes substantially enhanced ROS generation upon excitation by specific wavelength thus resulting in a targeted ROS-based ER stress.
This particularly sensitive procedure is ROS dependent and occurs in the ER where disulfide bond formation takes place during the folding process.
Other pro-apoptotic factors may be transcriptionally activated by CHOP [ 3738 ].
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