Synthesis of diethyl malonate from malonic acid
Brought temperature up to 33C using a water bath.
The water layer was discarded. Our editors will review what you've submitted, and if it meets our criteria, we'll add it to the article.
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The single most important condition for a successful synthesis is good mixing - Nicodem. Your contribution may be further edited by our staff, and its publication is subject to our final approval. I reported the synthesis of the acid in a previous thread, "Oxidation of Diols.
DEAM can be acetylated to produce diethyl acetamidomalonate useful in amino-acid synthesisor can be added with 3-substituted 2,4-diketones to boiling acetic acid to afford in maximal yield variously substituted ethyl pyrrolecarboxylates of interest for porphyrin synthesis.
Although I have spent a lot of energy on this already I'd be willing to do more experimentation if I could get some encouraging suggestions about what to do differently.
Your discussion and suggestions are welcomed. I'm sorry if this long dissertation has become tedious but I thought that only through providing all detail could I hope for any constructive suggestions.
This was placed in an oil bath in a simple a perfect summer day essay set-up. Please note that our editors may make some formatting changes or correct spelling or grammatical errors, and may also contact you if any clarifications are needed. The carbanion 2 formed by reacting diethyl malonate 1 with a suitable base can be alkylated with a suitable electrophile.